With the NFL schedule revealed last week, the Las Vegas based sportsbook Check out the odds for every game Week 1 to 16 below (home team's odds in parentheses). New York Giants at Dallas Cowboys (- 5, ). Monday Sept. 11, New Orleans Saints at Minnesota Vikings (-3, 48). NFL odds and spreads for the latest NFL games. NFL Odds: Week 1. Preseason Week 4 Arizona Cardinals () at Detroit Lions (). Sun, Sep 10, . New Orleans Saints () at Minnesota Vikings (). Mon, Sep Betting on the favorite means the team must win by at least fourteen points to cover the spread. Find out the odds and daily lines for upcoming NFL pro football games. NFL Daily Lines - Week5 (Preseason) POINT SPREAD, TOTAL, MONEY LINE . NY Giants at New England - Thu, Aug 31, PM ET () .. Â' The common misconception is that Las Vegas sets the spread as its best guess at the margin of.