Week 1 is approaching and there are several fantasy defenses with great matchups to exploit. Alex Gelhar explains why the Buffalo Bills and. RotoGrinders teams up with Inside The Pylon to bring you a closer look at some key NFL matchups to focus on for your Week 1 lineups. Week 1 of the NFL preseason is finally here. NFL Preseason Complete Week 1 Schedule, Odds and Expert Predictions talent and give valuable snaps to players on the fringes of the roster before making cuts.